Approximately 25 million Americans suffer from superficial venous reflux disease. Superficial venous reflux disease is not limited to unsightly varicose veins. One can have superficial venous reflux disease alone, superficial venous reflux disease with varicose veins, or varicose veins without venous reflux disease.
Venous reflux or venous insufficiency develops when the valves that usually keep blood flowing out of your legs become diseased and don't function as one-way valves. The blood 'refluxes' back into the legs. In essence, it is like gastroesophageal reflux disease (GERD) when acid in the stomach goes the wrong way - instead of moving down into the small intestine, it refluxes into the esophagus, causing acid reflux symptoms. Venous reflux is venous blood being pushed back into the legs, instead of it moving towards the heart and lungs for proper oxygenation. This pooling of blood and this pressure force generates varicose veins and all of the problems such as discoloration of the skin with bronzing, pigmentation and eventually skin ulceration - called venous stasis ulceration. The likelihood of venous stasis ulceration as a lifetime risk in individuals with venous reflux disease is 1 in 24.
The Cochrane Collaboration studied escin based on the premise that "conservative therapy of chronic venous insufficiency (CVI) consists largely of compression treatment. This often causes discomfort and has been associated with poor compliance. Therefore, oral drug treatment is an attractive option". Their research demonstrated that "there was an improvement in chronic venous insufficiency (CVI) related signs and symptoms with horse chestnut extract compared with placebo. According to their analysis of the published literature, "leg pain was assessed in seven placebo-controlled trials. Six of these trials reported a significant reduction of leg pain in the horse chestnut extract groups compared with the placebo groups, while another study reported a statistically significant improvement compared with baseline". The meta analysis of these trials by the Cochrane Collaboration as it relates to venous insufficiency and horse chestnut extract (escin) in effect demonstated that "horse chestnut extract may be as effective as treatment with compression stockings. Adverse events were usually mild and infrequent".
The Cochrane Collaboration is a very prestigious research group with a lot of weight being attributed to these types of practice guideline recommendations. Uberceuticals is not affiliated with the Cochrane Collaboration.
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Take one capsule of Veinamin® AM in the morning, preferably with food. Horse chestnut extract and Gotu Kola can be taken with all medications except for the blood thinner coumadin, trade name Warfarin®. Take one capsule of Veinamin® PM in the evening, preferably with food. Horse chestnut extract and bilberry can be taken with all medications except for the blood thinner coumadin - Warfarin®. We recommend that you take Veinamin® AM in conjunction with Veinamin® PM for maximal efficacy and proper dosing of the active ingredients of these dietary supplements.
Unless recommended by your doctor, do not take Veinamin products with the blood thinner coumadin (warfarin) or their equivalents (heparin, lovenox, etc).